Healing Potential of Cabbage and Radish Extracts on Prediabetes

Greg Howard
9th July, 2024

Healing Potential of Cabbage and Radish Extracts on Prediabetes

Image Source: Natural Science News, 2024

Key Findings

  • The study by Universidad Autónoma de Yucatán evaluated green cabbage and radish extracts on prediabetic rats
  • Green cabbage extract significantly reduced feed intake and weight gain in the rats
  • Both extracts decreased fasting glucose and insulin levels, improving glucose tolerance and insulin sensitivity
  • The extracts provided protective effects on the pancreas and liver, showing minor damage compared to the control group
Type 2 diabetes (T2D) is a growing health concern worldwide, characterized by insulin resistance and high blood sugar levels. The search for effective treatments is ongoing, with recent research focusing on natural products. A study conducted by the Universidad Autónoma de Yucatán evaluated the effects of aqueous extracts from Brassica oleracea (green cabbage) and Raphanus sativus (radish) on prediabetic rats induced by a high-sucrose diet (HSD)[1]. This study aimed to explore the potential of these extracts in managing T2D. The research involved administering B. oleracea (BAE) and R. sativus (RAE) extracts to male Wistar rats at doses of 5 and 10 mg/kg over five weeks. The rats were monitored for changes in weight, blood glucose levels, and insulin resistance. The study also examined the histological impact on the pancreas and liver, crucial organs in glucose metabolism and insulin production. The findings revealed that BAE significantly reduced feed intake and weight gain in the rats. Both BAE and RAE extracts decreased fasting glucose and insulin levels, although these reductions were not statistically significant. However, both extracts significantly reduced the homeostatic model assessment for insulin resistance and β-cell function, indicating improved glucose tolerance and insulin sensitivity. Histological analysis showed that the extracts provided protective effects on the pancreas and liver, with minor damage observed compared to the control group. These results align with previous studies on the role of natural products in managing metabolic disorders. For instance, radishes have been associated with antidiabetic effects, enhancing antioxidant defenses, promoting glucose uptake, and reducing glucose absorption in the intestine[2]. This study adds to the body of evidence supporting the therapeutic potential of cruciferous vegetables in T2D management. The study's findings are particularly relevant in the context of metabolic syndrome (MetS), a cluster of conditions including obesity, hypertension, and insulin resistance, which significantly increases the risk of T2D[3]. The extracts' ability to improve glucose regulation and protect pancreatic β cells highlights their potential in preventing the progression from MetS to T2D. Understanding β cell dysfunction and adaptation in MetS is crucial, as these cells are responsible for insulin production and secretion. Moreover, the study's results are consistent with research on the effects of hyperuricemia and insulin resistance. Elevated uric acid levels can induce insulin resistance in skeletal muscle, a key site for glucose uptake and storage[4]. Metformin, a common antidiabetic drug, ameliorates this condition by enhancing glucose uptake through the activation of AMPK and GLUT4 translocation. The similar effects observed with BAE and RAE extracts suggest they may share mechanisms with metformin, offering a natural alternative with fewer side effects. The exploration of medicinal herbs and natural products is gaining traction due to the limitations and side effects of conventional antidiabetic drugs[5]. Bioactive molecules from plants have shown promise in improving β cell function, insulin resistance, and glucose homeostasis. The study by the Universidad Autónoma de Yucatán contributes to this field by demonstrating the potential of BAE and RAE in managing prediabetic conditions and preventing T2D. In conclusion, the study indicates that aqueous extracts from green cabbage and radish can reduce weight gain, improve glucose regulation, and protect the pancreas and liver in prediabetic rats. These findings support the therapeutic potential of cruciferous vegetables in preventing and managing T2D, offering a natural complement to existing treatments. Further research and clinical trials are needed to confirm these effects in humans and explore their mechanisms of action.

MedicineHealthBiochem

References

Main Study

1) Therapeutic Potential of Brassica oleracea and Raphanus sativus Aqueous Extracts on a Prediabetic Rat Model.

Published 8th July, 2024

https://doi.org/10.1089/jmf.2023.0022


Related Studies

2) Radish (Raphanus sativus) and Diabetes.

https://doi.org/10.3390/nu9091014


3) β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes.

https://doi.org/10.1172/JCI129188


4) Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.

https://doi.org/10.1016/j.mce.2016.12.025


5) Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.

https://doi.org/10.1155/2020/1356893



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