Study on the Benefits of Black Seed Oil in Reducing Seasonal Allergy Symptoms

Greg Howard
10th August, 2024

Study on the Benefits of Black Seed Oil in Reducing Seasonal Allergy Symptoms

Image Source: Natural Science News, 2024

Key Findings

  • The study found that Nigella sativa oil (NSO) combined with piperine significantly reduced nasal and ocular symptoms of allergic rhinitis (AR) compared to a placebo
  • Participants taking NSO reported a greater overall improvement in their AR symptoms and quality of life
  • The supplement was well-tolerated with no significant changes in vital signs or other health markers, indicating its safety for use
Allergic rhinitis (AR), commonly known as seasonal allergies, affects millions worldwide, causing symptoms such as sneezing, nasal congestion, nasal itching, and nasal discharge. While various treatments exist, there is growing interest in evidence-based natural medicines and supplements. A recent study conducted by Sami-Sabinsa Group Limited investigated the potential of Nigella sativa oil (NSO) combined with piperine as a bioavailability enhancer in managing AR symptoms[1]. The study was a randomized, double-blind, placebo-controlled trial involving 65 participants aged 18 to 60 years, all experiencing at least two allergic symptoms for more than an hour daily. Participants received either a capsule of NSO (250 mg) with 2.5 mg piperine or a placebo, twice daily after meals, for 15 days. The primary objectives were to observe changes in the Total Nasal Symptom Score and the duration of AR symptoms from baseline to Day 15. Secondary endpoints included changes in the Total Ocular Symptoms Score, AR symptom frequency and severity, serum Immunoglobulin E levels, and the Patient Global Impression of Change scale. Results showed a significant reduction in both the Total Nasal Symptom Score and the Total Ocular Symptoms Score in the NSO group compared to the placebo group. The frequency and severity of AR symptoms per day also decreased more significantly in the NSO group. Additionally, participants in the NSO group reported greater improvement in the Patient Global Impression of Change scale. Although serum Immunoglobulin E levels decreased in the NSO group, the difference was not statistically significant compared to the placebo group. Importantly, no clinically significant changes were observed in vital signs, liver and renal function, lipid profile, hematology, fasting blood sugar, or urine analysis, indicating that the supplement was well-tolerated. This study aligns with previous findings on the efficacy of natural treatments for rhinitis. For instance, Nigella sativa has been recognized for its immunomodulatory and anti-inflammatory properties[2]. These properties are likely contributing factors to its effectiveness in reducing AR symptoms. The current study builds on this by providing evidence from a controlled clinical trial, supporting the use of NSO as a viable supplement for AR management. Moreover, the study’s methodology and findings complement earlier research on AR treatments. Intranasal corticosteroids (INCS) remain the preferred monotherapy for persistent AR, with intranasal antihistamines also being effective[3]. However, the current study suggests that NSO could serve as an alternative or adjunctive therapy, particularly for individuals seeking natural treatment options. This is significant given the increasing prevalence of rhinitis globally and the variability in its presentation across different regions[4]. The role of histamine in allergic reactions is well-documented, and second-generation H1-antihistamines have been a cornerstone in AR treatment due to their efficacy and safety profile[5]. The current study does not directly compare NSO with these antihistamines but adds to the body of evidence supporting the potential of natural compounds in managing AR symptoms. In conclusion, the study conducted by Sami-Sabinsa Group Limited demonstrates that NSO combined with piperine is an effective and well-tolerated supplement for managing AR symptoms. This finding is particularly relevant for individuals seeking natural alternatives to conventional AR treatments. Further research could explore the long-term efficacy and safety of NSO, as well as its potential role in combination with other AR therapies.

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References

Main Study

1) A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy.

Published 9th August, 2024

https://doi.org/10.1097/MD.0000000000039243

Related Studies

2) Immunomodulatory and therapeutic properties of the Nigella sativa L. seed.

Journal: International immunopharmacology, Issue: Vol 5, Issue 13-14, Dec 2005

3) Rhinitis 2020: A practice parameter update.

https://doi.org/10.1016/j.jaci.2020.07.007

4) Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution.

https://doi.org/10.1002/clt2.12130

5) Histamine and H1-antihistamines: celebrating a century of progress.

https://doi.org/10.1016/j.jaci.2011.09.005


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