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Natural Plant Compounds Inhibit Harmful Bacteria and Enzyme Activity
Jenn Hoskins
12th July, 2024
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Image Source: Natural Science News, 2024
Key Findings
- The study by the University of Karachi found that plant-derived compounds from sumac, pomegranate, and Indian almond can inhibit urease activity and bacterial growth
- Sumac extracts showed the strongest inhibition, with minimum inhibitory concentrations (MIC) ranging from 6 to 25 mg/mL
- The anthocyanin fractions were particularly effective, with MICs between 6 to 12 mg/mL, and demonstrated strong urease inhibition with low IC50 values (21-116 μg/mL)
References
Main Study
1) Inhibitory effect of polyphenols from sumac, pomegranate and indian almond on urease producing bacteria and jack bean urease activity.
Published 8th July, 2024
https://doi.org/10.1016/j.ijbiomac.2024.133735
Related Studies
2) Suppression of urease levels in Streptococcus salivarius by cysteine, related compounds and by sulfide.
Journal: Oral microbiology and immunology, Issue: Vol 15, Issue 5, Oct 2000
3) Klebsiella pneumoniae: Going on the Offense with a Strong Defense.
4) Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?
5) Flavonoids and related privileged scaffolds as potential urease inhibitors: a review.