Pomegranate Juice and Its Impact on Inflammation Markers

Greg Howard
2nd April, 2024

Pomegranate Juice and Its Impact on Inflammation Markers

Image Source: Natural Science News, 2024

Key Findings

  • Study at Mashhad University found pomegranate juice lowers inflammation marker CRP
  • The juice's effect was notable in women, older adults, diabetics, and those with PCOS
  • Optimal dose and duration for anti-inflammatory benefits are still unknown
Pomegranate juice, known for its rich polyphenol content and antioxidants, has long been considered a healthy dietary supplement with potential anti-inflammatory effects. This idea has been explored in various contexts, from managing conditions like polycystic ovary syndrome (PCOS)[2] to potentially aiding in the reduction of obesity[3] and improving cardiovascular health[4]. Despite its popularity and historical use in traditional medicine, the scientific community has been uncertain about the extent of pomegranate juice's impact on inflammation, particularly as measured by C-reactive protein (CRP) levels in the blood. CRP is a substance produced by the liver that increases in concentration in response to inflammation[5]. Elevated CRP levels are linked to a range of health issues, including heart disease and metabolic disorders, making it a critical focus for researchers. A recent systematic review and meta-analysis conducted by researchers at Mashhad University of Medical Sciences[1] sought to shed light on this topic by evaluating the effect of pomegranate juice supplementation on CRP levels. The study updated previous findings, which had shown no significant impact of pomegranate juice on CRP. By carefully analyzing data from 11 studies involving 696 participants, the researchers aimed to provide a more conclusive answer. The findings of this comprehensive analysis were striking. The meta-analysis revealed that pomegranate juice supplementation resulted in a significant decrease in CRP levels compared to control groups, with a weighted mean difference of -2.55 mg/L. This suggests that pomegranate juice does indeed have an anti-inflammatory effect, at least as indicated by CRP levels. Interestingly, the study found that the reduction in CRP was particularly significant in certain subgroups. These included studies that involved both sexes or only females, as well as those conducted on the Iranian population, individuals aged 40 years or older, patients with type 2 diabetes, and those with PCOS[2]. Moreover, the effect was observed in trials where the pomegranate juice dosage was less than 250 ml/day. Despite these encouraging results, the researchers noted that the relationship between the duration and dose of pomegranate juice supplementation and changes in CRP levels did not follow a clear linear or nonlinear pattern. This suggests that while pomegranate juice can be beneficial, the optimal dose and duration of supplementation to achieve the best anti-inflammatory effects are yet to be determined. The current study builds upon earlier research, such as the findings that pomegranate juice can reduce systolic and diastolic blood pressure and improve markers of endothelial function[4], and that it may have a role in managing the hormonal imbalances associated with PCOS[2]. These studies, together with the latest meta-analysis, provide a growing body of evidence supporting the health benefits of pomegranate juice. In conclusion, the latest research from Mashhad University of Medical Sciences indicates that pomegranate juice supplementation can significantly reduce CRP levels, suggesting an anti-inflammatory effect. While this is a promising development, further research is needed to fully understand the mechanisms at play, establish the most effective dosages and durations for supplementation, and confirm these effects in larger, more diverse populations. With such information, pomegranate juice could become an even more valuable component of dietary strategies aimed at reducing inflammation and promoting overall health.



Main Study

1) The effect of pomegranate juice supplementation on C-reactive protein levels: GRADE-assessed systematic review and dose-response updated meta-analysis of data from randomized controlled trials.

Published 30th March, 2024


Related Studies

2) The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: A randomized controlled trial.


3) Obesity: the preventive role of the pomegranate (Punica granatum).


4) Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects.


5) It's time to redefine inflammation.


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