Skincare Product with Oat Sap and Mangosteen Extract Reduces Acne Symptoms

Greg Howard
26th July, 2024

Skincare Product with Oat Sap and Mangosteen Extract Reduces Acne Symptoms

Image Source: Natural Science News, 2024

Key Findings

  • The study, conducted by Pierre Fabre Dermo-Cosmétique, tested the anti-inflammatory effects of Rhealba® oat sap and Garcinia mangostana extract on acne
  • In lab tests, these extracts significantly reduced inflammation-causing proteins produced by acne bacteria
  • In a clinical trial with 54 acne patients, the product containing these extracts reduced acne lesions and improved skin appearance over two months
Acne vulgaris is a common chronic inflammatory disorder affecting the pilosebaceous unit, which includes the hair follicle and its associated sebaceous gland. This condition manifests primarily on the face and upper back, characterized by papules, pustules, and nodules that can leave scars, post-inflammatory hyperpigmentation (PIH), and erythema (PIE)[1]. Despite being prevalent, especially among teenagers, acne can persist into adulthood, particularly affecting women[2]. Traditional treatments have varied efficacy and can come with significant side effects[3]. A recent study conducted by Pierre Fabre Dermo-Cosmétique aimed to evaluate the anti-inflammatory properties of a protein-free sap from Rhealba® oat plantlets and a Garcinia mangostana extract on Cutibacterium acnes-induced inflammation in vitro. Additionally, the study assessed the tolerability and efficacy of a dermocosmetic product containing these actives in subjects with mild-to-moderate acne. In the in vitro part of the study, monocyte-derived dendritic cells (Mo-DCs) from acne patients were stimulated with a planktonic culture of C. acnes, a bacterium known to colonize hair follicles and contribute to acne inflammation[3]. The researchers then measured the production of cytokines—proteins that signal inflammation—before and after the addition of the test extracts using RT-PCR and ELISA techniques. The results showed that the Garcinia mangostana extract and oat sap significantly reduced the synthesis of inflammatory cytokines IL-6, IL-12p40, IL-10, and TNFα, indicating strong anti-inflammatory properties. The clinical component of the study involved 54 subjects with mild-to-moderate acne. Participants applied the product containing the test extracts to their face and upper back twice daily for two months. The study found that the product was well tolerated by the subjects and led to significant decreases in the number of both retentional (non-inflammatory) and inflammatory acne lesions. Specifically, there was a 21% reduction in retentional lesions for 69% of subjects and a 35% reduction in inflammatory lesions for 79% of subjects by day 57. Furthermore, the Global Acne Evaluation severity scores improved over the study period, decreasing from 2.5 at the start to 2.2 at day 29 and 2.1 at day 57. Dermatologists rated the product as effective or very effective in most subjects with PIE (82%) and PIH (70%) by the end of the study. This is particularly important as post-inflammatory pigmentation issues are often more distressing to patients than the acne itself, especially in individuals with darker skin tones who are more prone to PIH[4]. The findings from this study suggest that the combination of Rhealba® oat sap and Garcinia mangostana extract could be a promising addition to acne management. The anti-inflammatory effects observed in vitro and the clinical efficacy demonstrated in subjects with mild-to-moderate acne support its use. This study builds on previous research that highlights the chronic nature of acne and the need for effective treatments that minimize side effects[2][3]. In conclusion, the study conducted by Pierre Fabre Dermo-Cosmétique offers new insights into acne treatment, showing that natural extracts can provide significant anti-inflammatory benefits and improve acne symptoms and related pigmentation issues. This research contributes to the ongoing quest for more effective and safer acne therapies, addressing a condition that affects individuals well beyond their teenage years[2].

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References

Main Study

1) A dermocosmetic product containing the sap of oat plantlets and Garcinia mangostana extract improves the clinical signs of acne.

Published 25th July, 2024

https://doi.org/10.1111/jdv.19876

Related Studies

2) The prevalence of acne in adults 20 years and older.

Journal: Journal of the American Academy of Dermatology, Issue: Vol 58, Issue 1, Jan 2008

4) The Pathogenesis and Management of Acne-Induced Post-inflammatory Hyperpigmentation.

https://doi.org/10.1007/s40257-021-00633-4


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