Fennel Extract-Based Sensor for Detecting Diclofenac Sodium in Medications

Jim Crocker
3rd June, 2024

Fennel Extract-Based Sensor for Detecting Diclofenac Sodium in Medications

Image Source: Natural Science News, 2024

Key Findings

  • Researchers at King Saud University developed a highly sensitive sensor for detecting the anti-inflammatory drug diclofenac sodium (DCF)
  • The sensor uses alumina (Al2O3) and cerium oxide (CeO2) nanoparticles, which enhance its electroactive properties
  • The sensor accurately measures DCF in both bulk and commercial products, with a high recovery rate of 99.95%
The recent study from King Saud University introduces a groundbreaking, ultrasensitive green functionalized sensor for determining the anti-inflammatory medication diclofenac sodium (DCF)[1]. This innovative approach utilizes alumina (Al2O3) and cerium oxide (CeO2) nanoparticles (NPs), which have gained significant attention for their exceptional electroactive properties in potentiometric and sensory research. The developed sensor offers a promising solution for accurately quantifying DCF in both bulk and commercial products. Inflammation is a natural protective response to tissue injury and infection, but chronic inflammation is implicated in various inflammatory disorders, including cancer and severe COVID-19 cases[2]. Anti-inflammatory drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs), play a crucial role in managing inflammation. However, conventional NSAIDs and selective COX-2 inhibitors (COXIBs) are associated with significant side effects, such as gastric, renal, and cardiac issues[2]. Moreover, some anti-inflammatory drugs can induce DNA damage upon UV-irradiation, raising concerns about their long-term safety[3]. To address these challenges, the current study explores the use of Al2O3 and CeO2 nanoparticles in developing a novel sensor for DCF detection. The research team employed various spectroscopic and microscopic techniques to confirm the formation of these nanoparticles. The fennel extract-mediated Al2O3/CeO2 nanocomposite (Al2O3/CeO2 NCS) modified coated wire membrane sensor demonstrated remarkable efficacy in quantifying DCF. The sensor development involved coupling diclofenac sodium with phosphomolybdic acid (PMA) to generate diclofenac phosphomolybdate (DCF-PM) as an active ion-pair in the presence of polyvinyl chloride (PVC) and o-nitrophenyl octyl ether (o-NPOE). UV-vis spectroscopy revealed clear peaks at 270 and 303 nm with band gaps of 4.59 eV and 4.09 eV for Al2O3 and CeO2, respectively. The crystallite sizes of the nanoparticles were determined using X-ray diffraction (XRD) to be 30.13 ± 8 nm for Al2O3, 17.72 ± 3 nm for CeO2, and 35.8 ± 0.5 nm for the Al2O3/CeO2 NCS. The developed sensor exhibited excellent linearity for DCF measurement, ranging from 1.0 × 10^-9 to 1.0 × 10^-2 mol L^-1, with a derived equation of EmV = (57.76) log [DCF] + 622.69. In comparison, the typical DCF-PM presented a potentiometric response range of 1.0 × 10^-5 to 1.0 × 10^-2 mol L^-1 and a regression equation of EmV = (56.97) log [DCF] + 367.16. The sensor's performance was validated by successfully determining DCF in commercial tablets with a percent recovery of 99.95 ± 0.3. The study's findings highlight the potential of using Al2O3/CeO2 NCS in developing highly sensitive and accurate sensors for pharmaceutical analysis. This approach not only addresses the need for precise DCF measurement but also aligns with the ongoing efforts to develop anti-inflammatory drugs with minimal side effects[2]. Additionally, the study's method validation adhered to international council harmonization requirements for analytical methodologies, ensuring the reliability and applicability of the proposed sensor. In summary, the research from King Saud University presents a significant advancement in the field of pharmaceutical analysis by introducing an ultrasensitive green functionalized sensor for diclofenac sodium detection. This innovative approach leverages the unique properties of Al2O3 and CeO2 nanoparticles, offering a promising solution for accurate and reliable DCF quantification in commercial products.

MedicineBiochemPlant Science


Main Study

1) Functionalized fennel extract-mediated alumina/cerium oxide nanocomposite potentiometric sensor for the determination of diclofenac sodium medication.

Published 15th June, 2024 (future Journal edition)


Related Studies

2) Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?


3) Sensitive spectrofluorimetric and mass spectroscopic methods for the determination of nucleic acid damage induced by photosensitized anti-inflammatory drugs: Comparative study.


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