Natural Blend of Burdock Root, Persimmon Leaf, and Quercetin Fights Gum Disease

Jenn Hoskins
21st May, 2024

Natural Blend of Burdock Root, Persimmon Leaf, and Quercetin Fights Gum Disease

Image Source: Natural Science News, 2024

Key Findings

  • The study by Ben's Lab Co., Ltd. tested BenTooth, a natural product mixture, for treating periodontitis
  • BenTooth showed strong antimicrobial activity against key bacteria causing periodontal disease
  • BenTooth reduced inflammation by lowering levels of specific enzymes and cytokines in lab tests
  • In a rat model, BenTooth prevented bone loss and promoted bone health, indicating its potential as a treatment for periodontitis
Periodontal disease is a widespread condition that leads to significant global morbidity. It is characterized by infection and inflammation of the periodontal tissue due to bacterial pathogens. A recent study conducted by Ben's Lab Co., Ltd.[1] aimed to evaluate the therapeutic efficacy of BenTooth, a natural product mixture containing burdock root extract, persimmon leaf extract, and quercetin, against periodontitis both in vitro (in the lab) and in vivo (in living organisms). Periodontitis, a common inflammatory disease, is initiated by bacterial biofilm, commonly known as dental plaque, affecting both the periodontal ligaments and bone surrounding teeth[2]. This condition can lead to the destruction of tooth-supporting structures, including connective tissue and bone[3]. The study by Ben's Lab Co., Ltd. sought to determine if BenTooth could offer a viable treatment option for this debilitating condition. The study conducted a series of tests to examine the antimicrobial properties of BenTooth and its impact on cellular responses related to inflammation and bone resorption. The results were promising. BenTooth demonstrated potent antimicrobial activity against two key bacterial pathogens, P. gingivalis and S. mutans. These bacteria are known to play a significant role in the development of periodontal disease. In the lab, BenTooth was tested on RAW264.7 cells, which are a type of macrophage cell line used to study inflammation. The results showed that BenTooth significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), both of which are enzymes involved in the inflammatory process. Additionally, it lowered the levels of inflammatory cytokines, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which are typically elevated due to P. gingivalis-derived lipopolysaccharide, a component that triggers inflammation. One of the critical aspects of periodontal disease is bone resorption, which leads to tooth loss. BenTooth was found to inhibit osteoclastogenesis, the process by which osteoclasts break down bone tissue. This inhibition was mediated by the receptor activator of nuclear factor κB ligand (RANKL), which plays a key role in bone metabolism. The study also included an in vivo component using a rat model of ligature-induced periodontitis. This model mimics the human condition of periodontal disease. In this experiment, rats that consumed BenTooth showed a significant reduction in the distance between the cementoenamel junction (CEJ) and the alveolar bone crest (ABC), indicating less bone loss. Additionally, these rats exhibited an increased bone volume fraction, suggesting that BenTooth not only prevents bone loss but may also promote bone health. These findings are significant because they suggest that BenTooth could be a potential therapeutic candidate for the prevention and treatment of periodontal diseases. This aligns with earlier studies that have highlighted the importance of managing inflammation and bacterial infection in treating periodontitis[2][3]. Furthermore, the study supports the notion that improving periodontal health can have broader systemic health benefits, potentially impacting conditions like cardiovascular disease and diabetes[2]. In conclusion, the study by Ben's Lab Co., Ltd. provides compelling evidence that BenTooth, an edible natural product mixture, has significant antimicrobial and anti-inflammatory properties that can mitigate the effects of periodontitis. By reducing inflammation and bone resorption, BenTooth offers a promising new approach to managing this common and debilitating condition.

MedicineHealthBiochem

References

Main Study

1) Antimicrobial and anti-inflammatory effects of BenTooth: A natural product blend of burdock root, persimmon leaf extracts, and quercetin on periodontal disease.

Published 30th May, 2024 (future Journal edition)

https://doi.org/10.1016/j.heliyon.2024.e30835

Related Studies

2) Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease.

https://doi.org/10.3390/ijms20061414

3) Primary immunodeficiencies reveal the essential role of tissue neutrophils in periodontitis.

https://doi.org/10.1111/imr.12724


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