![Natural Science News](images/logo.png)
Discovery of Anti-inflammatory Peptides from Jack Bean Protein for Gut Health
Jenn Hoskins
29th June, 2024
![Discovery of Anti-inflammatory Peptides from Jack Bean Protein for Gut Health](https://static.naturalsciencenews.com/images/articles/4580_main.jpg)
Image Source: Natural Science News, 2024
Key Findings
- Researchers from Hiroshima University studied the effects of Jack bean protein hydrolysate (JBPH) on intestinal inflammation
- JBPH significantly reduced the production of the inflammatory molecule IL-8 in human intestinal cells
- The anti-inflammatory effect of JBPH is due to its ability to inhibit key signaling pathways, specifically NF-κB and MAPK
References
Main Study
1) Identification and Molecular Mechanism of Anti-inflammatory Peptides Isolated from Jack Bean Protein Hydrolysates: in vitro Studies with Human Intestinal Caco-2BBe Cells
Published 28th June, 2024
https://doi.org/10.1007/s11130-024-01201-x
Related Studies
2) Jack Bean (Canavalia ensiformis) Tempeh: ACE-Inhibitory Peptide Formation during Absorption in the Small Intestine.
3) Isolation and identification of peptides from simulated gastrointestinal digestion of preserved egg white and their anti-inflammatory activity in TNF-α-induced Caco-2 cells.