Healing Power of NEO400 in Treating UV-Damaged Skin

Jim Crocker
7th July, 2024

Healing Power of NEO400 in Treating UV-Damaged Skin

Image Source: Natural Science News, 2024

Key Findings

  • Researchers at the University of Southern California developed a new compound, NEO400, to repair UVR-induced skin damage
  • NEO400, made by combining linoleic acid and perillyl alcohol, prevents skin damage when applied immediately after UVR exposure
  • NEO400 also accelerates healing in skin that has already sustained significant UVR damage, unlike Aloe vera gel
Excessive exposure to ultraviolet radiation (UVR) is known to cause harmful effects on human skin, such as DNA damage, inflammation, and an increased risk of skin cancer[2][3]. While pre-exposure application of sunscreen can provide protection, there is a significant need for agents that can repair damage after it has occurred. A recent study conducted by researchers at the University of Southern California has investigated a novel compound, NEO400, which appears to meet this medicinal need[1]. NEO400 was developed by conjugating linoleic acid to perillyl alcohol. Linoleic acid is an essential fatty acid commonly found in plant oils, while perillyl alcohol is a compound derived from certain essential oils. The researchers administered UVR to the skin of mice over several weeks, which resulted in typical UV-induced damage, including scaling of the skin, DNA damage, and elevated levels of inflammatory cytokines. However, when NEO400 was applied immediately post-UVR exposure, it triggered the appearance of markers for dermal stem cell proliferation, and no signs of skin damage emerged. Additionally, when NEO400 was applied to skin that had already sustained significant damage, it accelerated the healing process. The study found that neither linoleic acid nor perillyl alcohol alone was effective in providing these protective and healing effects. This indicates that the conjugation of the two compounds is necessary for therapeutic efficacy. Notably, the study also compared NEO400 to Aloe vera gel, a popular post-exposure remedy, and found that Aloe vera was ineffective in achieving the same skin-protective effects. The harmful effects of UVR, including DNA damage and the risk of skin cancer, are well-documented[2][3][4]. Chronic exposure to UVR can lead to photoaging, immunosuppression, and photocarcinogenesis, which involves the accumulation of genetic changes and immune system modulation, ultimately leading to skin cancers[2]. Light-skinned individuals are particularly at risk for both acute and long-term negative effects of UVR[3]. The development of melanoma, the deadliest form of skin cancer, is closely linked to UVR exposure, and factors such as hair color, skin type, genetic background, and history of tanning influence the skin's response to UVR[4]. The findings of the USC study suggest that NEO400 could serve as a regenerative treatment for excessively UVR-exposed skin, addressing a critical gap in post-exposure therapies. This is particularly important given the limitations of current remedies and the significant health risks associated with UVR exposure. The study expands on previous research by demonstrating a novel approach to mitigating UVR-induced skin damage and promoting skin healing. In summary, the USC study introduces NEO400 as a promising compound for repairing UVR-induced skin damage. By conjugating linoleic acid to perillyl alcohol, researchers have created a compound that not only prevents damage when applied immediately post-exposure but also accelerates healing in already damaged skin. This advancement holds potential for improving skin health and reducing the long-term risks associated with UVR exposure.



Main Study

1) Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage.

Published 5th July, 2024


Related Studies

2) Toxic effects of ultraviolet radiation on the skin.

Journal: Toxicology and applied pharmacology, Issue: Vol 195, Issue 3, Mar 2004

3) Mechanisms of and variables affecting UVR photoadaptation in human skin.


4) Mechanisms and prevention of UV-induced melanoma.


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