Ginseng Supplements and Heart Health: A Study on Benefits and Ideal Dosage

Jim Crocker
7th July, 2024

Ginseng Supplements and Heart Health: A Study on Benefits and Ideal Dosage

Image Source: Natural Science News, 2024

Key Findings

  • Researchers from Golestan University of Medical Sciences reviewed studies to evaluate ginseng's effect on heart disease risk factors
  • The review focused on lipid profiles, blood sugar control, body measurements, inflammation, blood pressure, oxidative stress, liver function, and heart rate
  • The study aims to determine if ginseng can be a natural supplement to existing heart disease treatments by modifying these risk factors
Heart diseases are a major global health issue, particularly prevalent among adults consuming Westernized diets. Cardiovascular diseases (CVDs) are characterized by disruptions in blood circulation and are influenced by various risk factors. A recent systematic review conducted by researchers from Golestan University of Medical Sciences aims to evaluate the efficacy of ginseng, a medicinal plant with a long history of use, in modifying several risk factors for CVD[1]. The study will focus on various parameters including lipid profiles, glycemic control, anthropometric indices, inflammation indicators, blood pressure, oxidative stress, liver function tests, adipokines, and heart rate among individuals aged 18 and above. To achieve this, the researchers will conduct an electronic search for articles published up to September 2023 from databases like PubMed, Scopus, Web of Science, CENTRAL, and EMBASE. The search will be limited to randomized controlled clinical trials involving both healthy and unhealthy participants. The quality of these studies will be assessed using the Cochrane risk of bias tool, with any discrepancies resolved through discussion with a third party. If enough eligible studies are found, a meta-analysis will be conducted. The significance of this study lies in its potential to provide a comprehensive evaluation of ginseng's role in modifying CVD risk factors, which could offer a natural adjunct to existing medical treatments. Previous studies have highlighted the importance of addressing variable cardiovascular risk factors for better prevention of CVDs. For instance, a narrative review emphasized the need for simple, practical guidelines for cardiovascular prevention tailored to national, cultural, and socioeconomic contexts[2]. This aligns well with the current study's aim to provide a thorough evaluation of ginseng, potentially offering a natural and culturally acceptable means of managing CVD risk factors. Additionally, the new study builds on existing knowledge about the pathogenesis and progression of CVDs, which are predominantly of atherosclerotic origin. Atherosclerosis leads to various cardiovascular complications such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease[3]. The identification and management of risk factors like hyperlipidemia, hypertension, diabetes, obesity, smoking, and lack of physical activity are crucial in reducing the global burden of CVDs. The current study's focus on lipid profiles, glycemic control, and other related parameters is particularly relevant in this context. Moreover, the study’s approach to evaluating inflammation indicators and oxidative stress is noteworthy. Previous research has shown that acute infections can exacerbate cardiovascular inflammation, increasing the risk of complications. For example, a study demonstrated that lipopolysaccharide, a component derived from Gram-negative bacteria, can activate neutrophils, leading to increased inflammation and atherosclerosis in hypercholesterolemic mice[4]. By assessing ginseng's impact on inflammation and oxidative stress, the current study could provide insights into natural methods of mitigating such inflammatory responses, thereby reducing CVD risk. The systematic review by Golestan University of Medical Sciences is a significant step towards understanding the potential benefits of ginseng in cardiovascular health. By focusing on a wide range of risk factors and employing rigorous methods to evaluate existing research, the study aims to provide a comprehensive assessment of ginseng's efficacy. This could lead to the development of new, natural strategies for managing CVD risk factors, complementing existing medical treatments and potentially reducing the global burden of cardiovascular diseases.

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References

Main Study

1) Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis.

Published 5th July, 2024

https://doi.org/10.1136/bmjopen-2023-080926


Related Studies

2) Management of Measurable Variable Cardiovascular Disease' Risk Factors.

https://doi.org/10.2174/1573403X14666180222102312


3) A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes.

https://doi.org/10.2174/1381612825666190925163827


4) Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion.

https://doi.org/10.1161/CIRCULATIONAHA.120.046677



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