Exploring How Ashwagandha Seeds Help Counteract Amoxicillin Side Effects

Jim Crocker
15th June, 2024

Exploring How Ashwagandha Seeds Help Counteract Amoxicillin Side Effects

Image Source: Natural Science News, 2024

Key Findings

  • The study by the National Research Centre, Egypt, investigated the protective role of Ashwagandha seed extract (ASE) against amoxicillin (AMX)-induced toxicity in rats
  • AMX treatment significantly increased DNA damage, oxidative stress, and sperm abnormalities in brain, liver, and testis tissues
  • ASE treatment reduced genetic changes, oxidative stress markers, and sperm abnormalities in a dose-dependent manner, with higher doses providing more benefits
Amoxicillin (AMX) is a widely used antibiotic, particularly in pediatric medicine, but its potential adverse effects on various body organs have raised concerns. Prior studies have documented AMX's neurotoxic effects, including increased oxidative stress and neurotransmitter imbalances in juvenile rats[2], as well as its detrimental impact on oxidative stress and reproductive health in mice[3]. Building upon these findings, a recent study conducted by the National Research Centre, Egypt, aimed to evaluate the protective role of Ashwagandha seed extract (ASE) against AMX-induced toxicity[1]. The study involved treating rats with AMX at a dose of 90 mg/kg, with and without ASE at doses of 100, 200, and 300 mg/kg. The researchers conducted several assessments, including DNA comet assays, cytogenetic examinations, sperm-shape analysis, and evaluations of malondialdehyde (MDA) levels—a marker for oxidative stress. Additionally, histopathological examinations and biophysical tests were performed to assess changes in brain tissue. The results revealed that AMX treatment significantly increased DNA damage, cytogenetic aberrations, and MDA content in brain, liver, and testis tissues, alongside sperm-shape anomalies. These findings align with earlier studies that highlighted AMX's role in increasing oxidative stress and disrupting normal cellular functions[2][3]. Notably, the study found that ASE treatment significantly reduced these genetic changes, oxidative stress markers, and sperm abnormalities. The protective effects of ASE were dose-dependent, with higher doses providing more pronounced benefits. Histopathological examinations showed that AMX induced neurotoxicity in brain tissue, consistent with previous findings of AMX-related neurological adverse effects such as convulsions and altered neurotransmitter levels[2]. ASE treatment partially mitigated these damages, with therapeutic ASE showing more noticeable positive effects compared to protective ASE. This suggests that ASE not only prevents but also reverses some of the neurotoxic effects of AMX. Biophysical parameters, including modulus, relaxation time, permittivity, entropy, and internal energy change of the brain, were also evaluated. These measures provide insights into the physical properties and stability of brain tissues. The study found that therapeutic ASE improved relaxation time, permittivity, and free energy change more effectively than protective ASE. Both forms of ASE treatment were able to recover entropy and internal energy changes to varying degrees, indicating a restoration of normal cellular function and stability. The study's findings underscore the potential of ASE as a protective agent against AMX-induced toxicity. By reducing DNA damage, oxidative stress, and neurotoxicity, ASE could offer a therapeutic strategy to mitigate the adverse effects of AMX, particularly in vulnerable populations such as children. This research not only builds on previous studies that highlighted the harmful effects of AMX[2][3] but also introduces a potential solution to counteract these effects, thereby contributing to safer antibiotic use and improved health outcomes.

MedicineHealthBiochem

References

Main Study

1) Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity.

Published 14th June, 2024

https://doi.org/10.1093/toxres/tfae091


Related Studies

2) Evidence for neurotoxicity associated with amoxicillin in juvenile rats.

https://doi.org/10.1177/0960327115607948


3) Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress.

https://doi.org/10.1080/13813455.2018.1482354



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